Author/Editor     Pirš, Mateja; Poljak, Mario; Seme, Katja; Babič, Dunja Z; Tomažič, Janez
Title     Clinical features and virologic characteristics of primary and early HIV-1 infection in Slovenian patients
Type     članek
Source     Coll Antropol
Vol. and No.     Letnik 30, št. Suppl 2
Publication year     2006
Volume     str. 47-52
Language     eng
Abstract     Analysis of time trends in newly diagnosed HIV-1 infected patients in Slovenia over a 10-year period (1996-2005) showed an increase in the number of newly diagnosed HIV-1 infected patients in 2004 and 2005 as well as increase in the number of newly diagnosed patients with primary/early HIV-1 infection. A retrospective analysis was performed in order to evaluate the clinical, epidemiological, laboratory and virological parameters of primary/early HIV-1 infection presenting with or without acute retroviral syndrome (ARS). Primary/early HIV-1 infection was diagnosed in 33 (19.5%) out of 169 newly diagnosed HIV-1 infected patients during the 10-year period. Most patients experienced ARS, the most commonly reported symptoms being fever, malaise and pharyngitis, followed by rash and lymphadenopathy. Median CD4 cell count was 415 cells/mm3, median CD8 cell count was 865 cells/mm3 and median HIV-1 viral load at the time of diagnosis was 5.1 loglo copies/mL. The increase in the number of newly diagnosed HIV-1 infected patients may be in part due to increased awareness among clinicians of the possibility of ARS, and the possibility of increased awareness of symptoms of ARS among persons at high risk of infection.
Descriptors     DISEASE OUTBREAKS
BLOOD STAINS
HIV-1
GENES, POL
HIV INFECTIONS
HIV-1
HOMOSEXUALITY, MALE
PHYLOGENY
RNA, VIRAL
SLOVENIA
ADULT
AGED
CROSS-SECTIONAL STUDIES
GENE PRODUCTS, GAG
HIV INFECTIONS
HIV-1
HLA-A2 ANTIGEN
PEPTIDE FRAGMENTS
PROSPECTIVE STUDIES
CORRESPONDENCE
HIV ANTIBODIES
HIV INFECTIONS
POLYMERASE CHAIN REACTION
ADULT
AGED
HIV INFECTIONS
RETROSPECTIVE STUDIES
SLOVENIA
VIRAL LOAD