Author/Editor		Podbregar, Matej; Gabršček, Lucija; Pakiž, Maja; Blinc, Aleš; Šabovič, Mišo; Kralj, Edvard
Title		Relation of ultrasound morphologic characteristics of central pulmonary artery thromboemboli to their ex vivo lysibility
Type		članek
Source		J Am Soc Echocardiogr
Vol. and No.		Letnik 20, št. 3
Publication year		2007
Volume		str. 276-80
Language		eng
Abstract		Background: Ultrasound morphology of massive central pulmonary artery thromboemboli (TE) is an independent predictor of 30-day mortality. The aim of this study was to asses ex vivo lysibility of morphologically different TE. Methods: Forty-five central pulmonary artery TE, collected at autopsies, were divided into hypoechoic (group A) and hyperechoic (group B) categories. TE were lysed with alteplase in a perfusing system simulating pulmonary circulation for 1 hour. Results: The grey scale mean of thrombi in group B was higher compared with group A (64 +/- 7 vs. 38 +/- 7, respectively, P < .01). Spontaneous lysis in group A did not differ compared with group B (2.2% +/- 0.5% vs. 2.1% +/- 0.4%, P = .4). After incubation with alteplase, the weight of TE was reduced more in group A than in group B (16% +/- 2% vs. 11% +/- 2%, P < .001). The grey scale mean negatively correlated with the percentage of TE weight reduction (0.768) (P < .001). Conclusion: Ultrasound morphology of TE from central pulmonary arteries correlates significantly with ex vivo lysibility. Hypoechoic TE are more susceptible to thrombolysis than hyperechoic TE.
Descriptors		AGED FIBRINOLYTIC AGENTS IMAGE INTERPRETATION, COMPUTER-ASSISTED PROGNOSIS PULMONARY ARTERY PULMONARY EMBOLISM THROMBOLYTIC THERAPY TREATMENT OUTCOME ULTRASONOGRAPHY