| Author/Editor | Kovačič, D; Marinšek, M; Gobec, L; Lainščak, M; Podbregar, M | |
| Title | Effect of selective and non-selective beta-blockers on body weight, insulin resistance and leptin concentration in chronic heart failure | |
| Type | članek | |
| Source | Clin Res Cardiol | |
| Vol. and No. | Letnik 97, št. 1 | |
| Publication year | 2008 | |
| Volume | str. 24-31 | |
| Language | eng | |
| Abstract | Background: Chronic heart failure (CHF) is characterized by increased insulin resistance and hyperleptinaemia. We aimed to study effects of selective and non-selective beta-blockers on body weight, insulin resistance, plasma concentrations of leptin and resistin in patients with CHF. Methods : Twenty-six non-cachectic beta-blocker-naive patients with CHF were randomized and treated with either carvedilol or bisoprolol. Body weight, plasma concentrations of leptin, resistin, fasting glucose and insulin were measured at baseline and after 6 months of therapy. Insulin resistance was estimated by homeostasis model assessment- estimated insulin resistance (HOMA-IR). Results : Body weight increased significantly in the carvedilol group (mean change + 2.30 kg, p = 0.023) while it did not change in the bisoprolol group (mean change -0.30 kg, p = 0.623) (ns between groups). Plasma leptin concentration increased only in the carvedilol group (mean change + 4.20 ng/ml, p = 0.019) (ns between groups). Fasting glucose and resistin remained unchanged in both groups. After 6 months, mean plasma insulin concentration changed significantly differently (p = 0.015) in the bisoprolol (mean change +3.1 microU/ml) compared to the carvedilol group (mean change -6.3 microU/ml) and HOMA-IR was consequently higher in the bisoprolol compared to the carvedilol group (5.2 +/- 4.2 vs 2.8 +/- 1.6, p = 0.046). Conclusion : This study found different metabolic effects of carvedilol and bisoprolol in non-cachectic patients with CHF. With unchanged fasting plasma glucose concentration after 6 months of treatment, carvedilol significantly decreased plasma insulin concentration and insulin resistance compared to bisoprolol. | |
| Descriptors | HEART FAILURE, CONGESTIVE ADRENERGIC BETA-ANTAGONISTS BODY WEIGHT INSULIN RESISTANCE ADIPOCYTES |