Author/Editor		Mavri, A; Alessi, MC; Juhan-Vague, I
Title		Hypofibrinolysis in the insulin resistance syndrome: implication in cardiovascular diseases
Type		članek
Source		J Intern Med
Vol. and No.		Letnik 255, št. 4
Publication year		2004
Volume		str. 448-56
Language		eng
Abstract		Insulin resistance syndrome (IRS) is associated with increased cardiovascular morbidity and mortality. IRS is becoming one of the major health problems as its prevalence grows rapidly. Accelerated atherothrombotic process in the IRS is attributed to metabolic abnormalities, inflammation and to impaired fibrinolysis due to increased plasma plasminogen activator inhibitor type 1 (PAI-1) levels. Proinflammatory cytokines may have an important role in PAI-1 overexpression, particularly in the adipose tissue. Studies in genetically modified mice indicate that PAI-1 might be involved in the aetiopathogenesis of obesity. Modifying PAI-1 expression by PAI-1 inhibitors may open a new field of research and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes.
Descriptors		INSULIN RESISTANCE PLASMINOGEN ACTIVATOR INHIBITOR 1 ATHEROSCLEROSIS THROMBOSIS OBESITY