Author/Editor		Alessi, Marie-Christine; Bastelica, Delphine; Mavri, Alenka; Morange, Pierre; Berthet, Bruno; Grino, Michel; Juhan-Vague, Irene
Title		Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation
Type		članek
Source		Arterioscler Thromb Vasc Biol
Vol. and No.		Letnik 23, št. 7
Publication year		2003
Volume		str. 1262-8
Language		eng
Abstract		Oobjective: Because obesity and insulin resistance (IR) are strongly associated with liver steatosis (LS), we investigated the relation between the degree of LS and plasminogen activator inhibitor-1 (PAI-1) in ob/ob mice, in C57/BL6 mice with alcoholic LS, and in severely obese humans. Methods and results: In both mouse models, plasma PAI-1 levels were associated with PAI-1 expression in the liver and with the degree of LS. Liver PAI-1 antigen was associated with the tumor necrosis factor receptor-II (TNFRII) antigen, whereas association with TNF antigen content was found in ob/ob mice only. No significant correlation between plasma PAI-1 and PAI-1 expression in adipose tissue of ob/ob mice was observed. Furthermore, the relation between plasma PAI-1 levels and body weight was positive in ob/ob mice but negative in C57/BL6 mice (both P<0.001). In humans, PAI-1 levels were correlated with the degree of LS, and 26% of plasma PAI-1 activity was independently explained by LS and serum insulin levels. Conclusions: Plasma PAI-1 levels are more closely related to fat accumulation and PAI-1 expression in the liver than in adipose tissue. In steatotic liver, PAI-1 antigen content is associated with those of TNF and TNFRII. Therefore, we suggest that TNF pathway dysregulation in LS could be involved in increased plasma PAI-1 in obesity with IR.
Descriptors		PLASMINOGEN ACTIVATOR INHIBITOR 1 FATTY LIVER INSULIN RESISTANCE RECEPTORS, TUMOR NECROSIS FACTOR ADIPOSE TISSUE BODY WEIGHT OBESITY BODY MASS INDEX MICE, INBRED C57BL