Author/Editor | Juhan-Vague, I; Alessi, MC; Mavri, A; Morange, PE | |
Title | Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk | |
Type | članek | |
Source | J Thromb Haemost | |
Vol. and No. | Letnik 1, št. 7 | |
Publication year | 2003 | |
Volume | str. 1575-9 | |
Language | slv, eng | |
Abstract | Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a core feature of insulin-resistance syndrome (IRS). Atherothrombotic complications in IRS are partly attributed to impaired fibrinolysis caused by increased plasma PAI-1 levels. Although the etiology of IRS is far from being explained, the clustering of inflammation, adipose tissue accumulation and insulin resistance suggests an etiopathological link. Proinflammatory cytokines might regulate PAI-1 expression in IRS; however, more studies are needed to confirm this complex mechanism in humans. Furthermore, modifying PAI-1 expression by PAI-1 inhibitors provides a new challenge and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes. | |
Descriptors | INSULIN RESISTANCE ANIMALS HEART DISEASES OBESITY PLASMINOGEN ACTIVATOR INHIBITOR 1 RISK |