Author/Editor     Tomaževič, T
Title     Vaginalni ultrazvučni monitoring u stimuliranim ciklusima kod postupka izvantjelesne oplodnje
Translated title     Vaginal ultrasound monitoring in stimulated cycles during in vitro fertilization programme
Type     članek
Source     Gynaecol Perinatol
Vol. and No.     Letnik 1, št. 1
Publication year     1992
Volume     str. 1-4
Language     cro
Abstract     In 1987, vaginal ultrasound was introduced for the follicle growth monitoring of the stimulated cycles in the IVF program. In 1988 the daily estradiol determination was reduced to 1-3 determinations per cycle. In several cycles there were no hormonal determinations. Some parameters and the results were compared in group A (196 stimulated cycles in 1987) with daily estradiol determinations and vaginal ultrasound measurements, in group B (792 cycles -1988-1989) with vaginal ultrasound measurements and 1-3 estradiol determinations, and in group C (79 cycles -1988-89) with vaginal ultrasound measurements for follicular growth monitoring only. The cycles were stimulated with human menopausal gonadotrophin (HMG) and with human chorionic gonadotrophin (HCG). The size of the dominant follicle (more than 16 mm) was the criterion for the application of HCG. The only indication was tubal infertility. The groups were matched fur age, the dosage of gonadotrophins, and for indication. As for transfer rates, there were no significant differences between the groups (83 per cent , 82 per cent ,86 per cent ). The same was true for the clinical pregnancy rates (16.1 per cent , 13.9 per cent , 19.7 per cent P less th. 0.05). The life birth rate in group C (16.7 per cent ) was significantly higher than in group A (10.1 per cent ) and group B (8.8 per cent ). Without diminishing the success rates, it was possible to reduce the number of hormonal determinations and the cost of the IVF procedure. Hormonal determinations are still needed in the cases of low and high responses to gonadotrophin stimulation as in the rare cases of a difficult vaginal ultrasound interpretation. Complementing the hormonal and vaginal ultrasound measurements in 69 cycles with a low response to gonadotrnphin stimulation (E2 less than 1 nmol L), it was possible to achieve a 7 per cent live birth rate.
Descriptors     FERTILIZATION IN VITRO
GRAAFIAN FOLLICLE
PREGNANCY
MONITORING, PHYSIOLOGIC
OVULATION INDUCTION
ESTRADIOL
COST-BENEFIT ANALYSIS