Author/Editor		Stanovnik, L; Logonder-Mlinšek, M
Title		Is mast cell histamine involved in the regulation of acid secretion in the guinea pig stomach?
Type		članek
Source		Agents Actions
Vol. and No.		Letnik 38
Publication year		1993
Volume		str. C298-C300
Language		eng
Abstract		In order to find out whether mast cell histamine is involved in acid secretion in the guinea pig stomach, we tried to answer the following questions. Can the calcium ionophore (CaI), A23 187, release enough mast cell histamine to evoke acid secretion? Does electrical stimulation of the vagus nerve (VS) provoke any changes in mast cells in the stomach? In the experiments, an isolated part ofguinea pig stomach was used. Preparations from CaI and VS treated groups were examined histologically at the end ofexperiments. CaI evoked a clear secretory response that was blocked by famotidine. The H2 antagonist also blocked the secretory effect of VS. This result shows that these secretory effects were at least partly mediated by the released histamine. Connective tissue mast cells in CaI treated preparations and in preparations with VS showed significant degranulation. These results support the hypothesis that mast cell histamine could be involved in gastric acid secretion in guinea pig stomach.
Descriptors		MAST CELLS HISTAMINE GASTRIC ACID GUINEA PIGS CALCIUM PARIETAL CELLS, GASTRIC