Author/Editor		Denišlič, M
Title		Multimodal evoked potentials and central motor latencies in evaluation of patients with optic neuritis
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 62, št. Suppl 1
Publication year		1993
Volume		str. 73-8
Language		eng
Abstract		Background. Optic neuritis (ON) is a frequent visual disorder in patients with multiple sclerosis (MS). After prolonged follow-up one third of patients with ON may develop demyelinating disease. The aim of our study was to evaluate clinical silent lesions of CNS occurring in patients with ON. The finding of silent lesions supprts the possible diagnosis of MS. Method. 15 patients with ON and 26 with possible, probable or definite MS were included. In ON patients, evoked potentials and transcranial cortical stimulation were performed. In the second group, visual pathway was assessed using visual evoked potentials. Results. In all patients with ON, delayed latencies of the wave P100 were recorded, while acoustic brain stem evoked potentials were abnormal in 20 percent, and somatosensory in 13 percent of patients. Delayed central motor latencies were noticed in 40 percent of the patients. In 9 patients (56 percent) with possible or probable MS, electrophysiological involvemenr of clinically unaffected eye was evaluated. Delayed visual evoked responses, indicating electrophysiologic dysfunction of unaffected optic nerve, were found in only 3 patients (19 percent) with definite MS. Conclusions. Visual evoked potentials are a very sensitive method in detection of optic nerve impairment, while neurophysiological evaluation of corticospinal pathway turned out to be the most sensitive method in doscovering clinically silent lesions in CNS.
Descriptors		MULTIPLE SCLEROSIS OPTIC NEURITIS EVOKED POTENTIALS, VISUAL REACTION TIME EVOKED POTENTIALS, SOMATOSENSORY