Author/Editor		Bratuš, Dejan; Hlebič, Gregor; Hajdinjak, Tine
Title		Relation between intracavernosal dose of prostaglandin Pge 1 and mean duration of erection in men with different underlying causes of erectile dysfunction
Type		članek
Source		Croat Med J
Vol. and No.		Letnik 48, št. 1
Publication year		2007
Volume		str. 76-80
Language		eng
Abstract		Aim To analyze differences in effect of intracavernosally applied alprostadil (prostaglandin PGE 1) on men with different underlying causes of erectile dysfunction. Methods Forty eight men with erectile dysfunction lasting for at least six months were stratified according to the etiology of erectile dysfunction into one of 4 groups comprising 12 patients. The groups were the following: psychogenic, arteriogenic, veno-occlusive, and neurological erectile dysfunction group. All men filled out International Index of Erectile Function (IIEF)-5 questionnaire, which is a 5-question version of International Index of Erectile Function Questionnaire, underwent clinical examination including neurological assessment, were tested for nocturnal penile tumescence, and had Doppler color sonography of penile arteries. Intracavernosal alprostadil was then applied to the patients, starting with a 5 [micro]g dose and then increased in 5 [micro]g increments until the final dose of 20 [micro]g was reached. We measured the time from the moment of application until the start of erection and time of erection duration. For statistical analysis, non-parametric Friedman test for significant differences between repeated measurements in small groups and Wilcoxon test for differences between doses were used. Results Significant relation was found between the applied dose of intracavernosal alprostadil and the duration of erection in all 4 groups of men with erectile dysfunction. In patients with arteriogenic erectile dysfunction, mean (+/- standard deviation) duration of erection for consecutive doses of alprostadil 5 [micro]g, 10 [micro]g, 15 [micro]g, and 20 [micro]g were 40.0 +/- 20.6, 54.6 +/- 23.6, 65.0 +/- 29.6, and 82.1 +/- 35.4 minutes, respectively, with significant increase for each dose. In patients with veno-occlusive dysfunction, mean durations of erection significantly increased from 8.2 +/- 7.8 minutes at 10 [micro]g to 17.3 +/- 9. (Abstract truncated at 2000 characters)
Descriptors		ALPROSTADIL ALPROSTADIL DOSE-RESPONSE RELATIONSHIP, DRUG PENILE ERECTION IMPOTENCE