Author/Editor		Debeljak, Nataša; Sytkowski, Arthur J
Title		EpoR
Type		članek
Source		Nature
Vol. and No.		Letnik 425
Publication year		2007
Volume		str. 1-11
Language		eng
Abstract		The erythropoietin receptor (EpoR) is a member of the cytokine receptor superfamily and is activated by its native ligand, erythropoietin (Epo). The primary function of Epo is to promote red blood cell production by stimulating erythroid progenitor cell proliferation and differentiation and maintaining viability of the progenitors in the bone marrow. To initiate this process, Epo binds to EpoR on the cell surface. Under normal conditions, the Epo-EpoR interaction is necessary for erythropoiesis to occur. Transgenic mice that lack EpoR exhibited severe anemia and died at embryonic day 13.5. This phenotype could be rescued by expression of human Epo or thrombopoietin (Tpo). Epo also appears to have multiple functions outside of hematopoiesis. Epo and EpoR have been identified on several non-hematopoietic cells and tissues. Epo regulates angiogenesis, is cardio- and neuroprotective, and is suggested to be tissue protective in the gastrointestinal system, reproductive tract and endothelium. EpoRs have been found on several types of tumors and malignant cells. However, research regarding the role of Epo and EpoR in cancer is sometimes contradictory.
Descriptors		RECEPTORS, ERYTHROPOIETIN ERYTHROPOIETIN BINDING SITES PHENOTYPE ERYTHROPOIESIS MICE, TRANSGENIC