Author/Editor		Kores-Plesničar, Blanka
Title		Razlike v načinu delovanja antidepresivov
Translated title		Differences in antidepressants' action
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 46, št. 1
Publication year		2007
Volume		str. 45-52
Language		slo
Abstract		Most antidepressants in use today are derivatives of the monoamine oxidase inhibitor iproniazide and the tricyclic agent imipramine. During the past several decades, approaches were undertaken to clarify the roles of the neurotransmitters norepinephrine, dopamine and serotonin in depression. By studying the effects of antidepressant medications on specific neurotransmitters, antidepressant therapies could be matched to treat specific symptoms of depression. Novel research has identified novel potential targets, with the goal of developing new antidepressant drugs with better efficacy and faster onset at action than the currently used gold standard treatments.
Summary		Številni antidepresivi, ki jih danes uporabljamo, izhajajo iz monoaminooksidaznega zaviralca iproniazida in iz tricikličnega antidepresiva imipramina. V preteklih desetletjih so raziskovanja skušala pojasniti vlogo nevrotransmiterjev noradrenalina, serotonina in dopamina pri depresiji. S proučevanjem učinkov antidepresivov na specifične nevrotransmiterje bi morda lahko zbrali ustrezno antidepresivno zdravilo, ki bi delovalo na specifične simptome depresije. Novejše raziskave že prepoznavajo nove potencialne tarče s ciljem razviti nova antidepresivna zdravila z boljšo učinkovitostjo in hitrejšim učinkovanjem, kot ga imajo sedanja zdravila zlatega standarda.
Descriptors		DEPRESSION ANTIDEPRESSIVE AGENTS