Author/Editor		Šenk, L; Pogačnik, M; Boehm, O; Prevorčnik, J; Tomažič, K
Title		Tuberkuloza (mikobakterioza) prašičev. 2. Študij pathohistoloških sprememb pri eksperimentalni okužbi s serovarom 4 Mycobacterium intracellulare
Translated title		Tuberculosis (mycobacteriosis) of pigs. 2. Study of the microscopic lesions in the lymph nodes of pigs, infected with Mycobacterium intracellulare serovar 4
Type		članek
Source		Zb Vet Fak Univ Ljublj
Vol. and No.		Letnik 29, št. 2
Publication year		1992
Volume		str. 219-34
Language		slo
Abstract		On basis of the study of pathohistological lesions in the organs and tissues of pigs experimentally orally infected with 120-140 million cells of Mycohucterium inlracellulure serovar 4, the following conclusions have been drawn: 1. In the tonsils and Peyer patches of the small intestire no primary lesions were found. 2. In the mesenterial lymph nodes, exceptionally in the mandibular ones, the lesions characteristic for the so called isolated tuberculosis of pigs were to be found. 3. On basis of the study of pathohistological lesions of pigs, sacrificcd at different days after infection, the pathogenesis of tuberculous lesions was deduced, as follows : a) The early changes appeared as indistictly demarcated accumulations of macrophages which transformed into epitheloid cells. The lesions had the character of proliferative tuberculosis with distinct infiltrative nature of growth of the tuberculous tissue. b) Allready at an early stage necrosis of macrophages was developing. As result of this the localized necrotic foci were to be found in the cource of time, with the formation of a capsule, consisting of specific tuberculous granulation tissue, on the outer side of the connective tissue. c) With the proliferative process in the early stage also giant cells occured which were in the first phase more of foreign-body type, later of typical Langhans type. In the later stages of the tuberculous process they were not found. d) Around the encapsuleted necrotic foci typical resorptive epitheloid tubereles formed into a conglomeration or multicentric necrotic foci. developed which centrally soon changed into necrosis, and later coalesced with the primary necrotic focus. In this way the primary necrotic foci grew and trans e) In the central part of the necrotic foci calcification occured early, but up to the 183rd day after infection the foci were not totally, calcified.(trunc.)
Descriptors		TUBERCULOSIS MYCOBACTERIUM AVIUM COMPLEX LYMPH NODES SWINE