Author/Editor		Rumboldt, Z; Šimunić, M; Bagatin, J; Rumboldt, M; Marinković, M; Janežič, A
Title		Controlled multicentre comparison of captopril versus lisinopril in the treatment of mild-to-moderate arterial hypertension
Type		članek
Source		Int J Clin Pharmacol Res
Vol. and No.		Letnik 13, št. 1
Publication year		1993
Volume		str. 35-41
Language		eng
Abstract		The antihypertensive efficacy and safety of lisinopril (L), a novel ACE inhibitor, were compared to those of captopril (C), the familiar drug of the same class, in a multicentre controlled trial. The study included 91 mild-to-moderate, middle-aged hypertensives of both genders, 46 of which were randomized to C and 45 to L. After a two-week placebo period the examinees were receiving either L o.d. in increasing dosage of 10, 20, or 40 mg per day (amount necessary to achieve normotension), or C b.i.d. in a corresponding daily dose of 25, 50, or 100 mg. During the eight-week formal part of the trial, L decreased the systolic blood pressure from the initial values by an average of 14.9 percent, and the diastolic pressure by some 15.2 percent. The same parameters were lowered on C by 11.2 percent, and 11.7 percent, respectively. The mean arterial pressure from an initial average of 125.5 mmHg was lowered to 110.9 mmHg on C (11.6 percent reduction, p : 0.01), and from 125.3 mmHg to 108.2 mmHg on L (13.6 percent reduction, p : 0.01). Although the L effects were more pronounced, the observed between-group differences did not reach the level of statistical significance, except for the achievement of normotension, which disclosed the superiority of L (p : 0.05). The tolerability of both drugs was good and only one examinee had to be excluded because of side-effects (proteinuria). It is concluded that both ACEIs under study showed comparable efficacy and safety, L being marginally more potent and longer acting.
Descriptors		ANTIHYPERTENSIVE AGENTS CAPTOPRIL DIPEPTIDES HYPERTENSION ADOLESCENCE ADULT AGED ANTIHYPERTENSIVE AGENTS BODY WEIGHT CAPTOPRIL CREATININE DIPEPTIDES ELECTROCARDIOGRAPHY HEART RATE HYPERTENSION MIDDLE AGE