Author/Editor		Serša, G; Novakovič, S; Miklavčič, D
Title		Potentiation of bleomycin antitumor effectiveness by electrotherapy
Type		članek
Source		Cancer Lett
Vol. and No.		Letnik 69, št. 2
Publication year		1993
Volume		str. 81-4
Language		eng
Abstract		Electrotherapy was investigated for its ability to increase the responsiveness of murine tumors to bleomycin treatment. Mice bearing fibrosarcoma were treated with 250 micrograms bleomycin and then with 0.6 mA direct current (DC) for 60 min. Antitumor effects of single treatments were moderate with bleomycin, but significant with electrotherapy. Combined treatment with bleomycin followed by electrotherapy was more effective than either treatment alone. Tumor growth delay of the animals after combined treatment was greater than the summation of tumor growth delays after single treatments. The results of our study indicate that bleomycin and electrotherapy treatments interact, with electrotherapy potentiating the effectiveness of bleomycin treatment.
Descriptors		BLEOMYCINS SARCOMA, EXPERIMENTAL COMBINED MODALITY THERAPY ELECTRIC STIMULATION THERAPY MICE MICE, INBRED A