Author/Editor		Koselj, M; Kveder, R; Bren, AF; Rott, T
Title		Acute renal failure in patients with drug-induced acute interstitial nephritis
Type		članek
Source		Ren Fail
Vol. and No.		Letnik 15, št. 1
Publication year		1993
Volume		str. 69-72
Language		eng
Abstract		The clinical features, laboratory evaluation, and outcome were analyzed in 23 patients with acute renal failure (ARF) and drug-induced acute interstitial nephritis (21 proven with biopsy). The groups of drugs implicated were: antibiotics (20 cases), nonsteroidal anti-inflammatory drugs (2 cases), and other drugs (phenobarbitone, 1 case). The clinical and laboratory signs of the disease appeared 3 to 28 days after exposure to the drug. Fever, skin rash, and flank tenderness were the most common clinical features observed (87 percent); and hematuria (100 percent), sterile pyuria (83 percent), and eosinophilia (39 percent) were established by laboratory tests. Hemodialysis (HD) was performed in 7 patients. Complete normalization of kidney function was observed in 3 patients; improvement to basal level in 3 patients (this group had preexisting renal disease); and CRF, requiring HD, in 1 patient. Renal function improved in all patients with mild to moderate renal insufficiency regardless of the therapy involved. Statistical evaluation could not confirm any significant differences between status of renal function at presentation, treatment (corticosteroids versus symptomatic and supportive measures only), and outcome of drug-induced acute interstitial nephritis (AIN). In summary, ARF due to drug-induced AIN has a favorable course with good prognosis regardless of the use or nonuse of corticosteroids in management strategy.
Descriptors		ANTIBIOTICS KIDNEY FAILURE, ACUTE NEPHRITIS, INTERSTITIAL ADULT KIDNEY FAILURE, ACUTE NEPHRITIS, INTERSTITIAL PROGNOSIS SLOVENIA