Author/Editor		Černe, Andreja; Bajc, Barbara; Kokalj, Anja; Kranjec, Igor; Bunc, Matjaž
Title		Učinkovitost antiagregacijskega zdravljenja po perkutani koronarni intervenci pri bolnikih s stabilno angino pektoris
Translated title		Efficacy of antiplatelet therapy in patients with stable angina pectoris undergoing percutaneous coronary interventions
Type		članek
Source		Slov Kardiol
Vol. and No.		Letnik 4, št. 2
Publication year		2007
Volume		str. 76-80
Language		slo
Abstract		There is considerable heterogeneity in the individual response to antithrombotic treatment. We aimed to investigate the effect of body mass index (BMI) on response to clopidogrel treatment. Methods. We included 33 consecutive patients with stable angina pectoris who underwent percutaneous coronary intervention (PCI) with stent insertion. AV patients were on aspirin 100 mg daily. A loading dose of clopidogrel 600 mg was administered immediately after stent placement, and maintenance dose of clopidogrel 75 mg was given for at least 1 month thereafter. Platelet aggregation in response to ADP, P-selectin expression and the Impact cone and platelet assay were evaluated at baseline, 24 hours and at one month after PCI. We compared different groups of patients based on their BMI. Clinical outcomes were also evaluated. Results Clopidogrel significantly decreased ADP-induced platelet aggregation at 24 hr and at 30 days after stent placement (47.1 t+-13.6% 27.5 +- 12.9% 35.5 +- 13.8% ANOVA p < 0.0001). There was no statistically significant deviations in P-selectin expression (2.3 +- 1.1%,1.9 +-0.9%,1.9 +- 0.9% p = ns). Platelet inhibition was not affected by BMI. Aspirin and clopidogrel resistance was found in 3.0°/ and 9.1 I of patients, respectively. Conclusions. In patients treated with aspirin, clopidogrel provides additional inhibition of platelet aggregation after loading dose as well as after one month period of treatment. The antiplatelet effect of clopidogrel was not affected by BMI. The connection between thrombotic complications and antiplatelet drug resistance was not established.
Descriptors		ANGINA PECTORIS ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY STENTS PLATELET AGGREGATION INHIBITORS ASPIRIN BODY MASS INDEX PLATELET AGGREGATION DRUG RESISTANCE