Author/Editor		Žvan, Bojana
Title		Protiagregacijska zdravila v sekundarni preventivi ishemičnega možganskožilnega dogodka. Slovenska priporočila
Translated title		Antiplatelet drugs in secondary prevention of cerebral ischemic event. Slovenian recommendations
Type		članek
Source		Slov Kardiol
Vol. and No.		Letnik 4, št. 2
Publication year		2007
Volume		str. 136-9
Language		slo
Abstract		Stroke risk is heightened among patients who have had a primary stroke or transient ischaemic attack. Because stroke recurrence can occur shortly after the primary event, European, American, as well as Sloevnian guidelines recommend initiating antiplatelet therapy as soon as possible. Aspirin, with or without extended-release dipyridamole, and clopidogrel are options for such patients. Low-dose aspirin (100 mg/day) has the same efficacy as higher doses but with less gastrointestinal bleeding. Clopidogrel remains an option for prevention of secondary events and may benefit patients with high risk of symptomatic atherothrombosis, but its combined use with aspirin can harm patients with unstable angina or non q wave myocardial infarction or patients with corronary or carotid angioplasty with stenting. Trials assessing aspirin plus dipyridamole have shown that the combination is more effective than aspirin monotherapy in preventing recurrent stroke. In choosing pharmacological therapy, the physician must consider the individual patient's risk factors and tolerance, as well as. Conclusion: Antiplatelet therapy is effective in secondary stroke prevention. Low dose aspirin can be used first-line, but aspirin plus extended-release dipyridamole improves efficacy. Clopidogrel is another option in secondary stroke prevention, especially for aspirin-intolerant patients, and its combined use with aspirin has only marginally better efficacy and increased bleeding risk, therefore the combination is not recommended in secondary stroke prevention.
Descriptors		CEREBRAL ISCHEMIA CEREBRAL INFARCTION PLATELET AGGREGATION INHIBITORS PRACTICE GUIDELINES