Author/Editor		Orel, Rok
Title		Probiotiki in njihova vloga pri črevesnih okužbah
Translated title		Probiotics and their role in intestinal infections
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 46, št. Suppl 2
Publication year		2007
Volume		str. 149-55
Language		slo
Abstract		Probiotics are live or non-viable micro-organisms, their cell components or products that when ingested have beneficial effect on human health. The majority of research work is done on their effect on therapy and prevention of gastrointestinal infections. Many clinical trials and meta-analyses of their results proved that probiotic use in acute diarrhea shortens episodes of diarrhea by approximately one day, and that their efficacy is better in children than in adults, increase with higher doses, and is higher in diarrhea caused by viruses, especially rotaviruses, than those caused by bacteria. Lactobacillus rhamnosus GG is the most studied probiotic in acute diarrhea. Although some results point to the possibility of effective prophylaxis of diarrhea with probiotics, the evidence is still scarce. Twenty to 60% of travellers from developed countries to developing countries exprience traveller's diarrhea. Although the results of probiotic use for the prevention of traveller's diarrhea are promising, they are also too conflicting to draw out any conclusion for routine use of probiotics. During antibiotic treatment, approximately 5% to 39% of patients suffer from of antibiotic-associated diarrhea as a resault of changes in normal intestinal bacterial microflora. Many clinical trials as well as meta-analyses of their results have shown, that the preventive use of probiotics, especially with the yeast Saccharomyces boulardii and Lactobacillus species, significantly decreases the risk for antibiotic-associated diarrhea. Clostridium difficile is the most important causative agent. Unfortunately, the results of clinical studies do not provide enough evidence for routine use of probiotics in the prevention of C. difficile diarrhea.
Descriptors		DIARRHEA ENTEROCOLITIS LACTOBACILLUS BIFIDOBACTERIUM STREPTOCOCCUS TRAVEL ANTIBIOTICS