Author/Editor		Štupar, Janez; Vrtovec, Matjaž; Dolinšek, Franci
Title		Longitudinal hair chromium profiles of elderly subjects with normal glucose tolerance and type 2 diabetes mellitus
Type		članek
Source		Metabolism
Vol. and No.		Letnik 56, št. 1
Publication year		2007
Volume		str. 94-104
Language		eng
Abstract		Longitudinal hair chromium (H-Cr) profiles in a group of patients with type 2 diabetes mellitus (n = 59; age, 62 ± 9 years) and healthy elderly (control) subjects (n = 49; age, 59 ± 10 years) matched by age and sex were measured by solid sampling electrothermal atomic absorption spectrometry, providing data on the magnitude of variation of Cr content along the hair length. H-Cr average (H-Crav) and H-Cr proximal (H-Crpr)., relating to the average Cr content of the whole hair and the proximal 3-mm hair length, respectively, were also obtained. No significant difference between the healthy and diabetic group was found in mean H-Crav or H-Crpr contents (248 ± 108 vs 247 ± 143 and 233 ± 98 vs 278 ± 195 micro g/g, respectively. However, women in the control group had significantly lower H-Cr values (P < .01) compared with men, but this difference was absent in the diabetic population. The distribution of log H-Crpr values in the control population displayed a Gaussian shape, in contrast to the substantially wider distribution, skewed toward lower H-Crpr values, observed in the diabetic group. The magnitude of variation in H-Cr content in the patient group over an interval of approximately 2 to 3 months (time of growth of the hair sampled) was found to be a factor of more than 2 larger than that in the control population (± 58% vs ± 26%). A strong relationship (R = 0.656; P < .01) between log H-Crpr and log fasting plasma Cr was observed in the diabetic group (n = 20). The mean fasting plasma Cr value of this group was 0.41 ± 0.10 micro g Cr per liter. No correlation between H-Crav. and duration of diabetes was observed. A strong positive association was observed in the control population between H-Crpr and fasting plasma insulin (n = 22; R = 0.6157; P < .01), and H-Crpr and fasting plasma glucose (n = 24; R = 0.4118; (Abstract truncated at 2000 characters)
Descriptors		CHROMIUM HAIR DIABETES MELLITUS, NON-INSULIN-DEPENDENT GLUCOSE TOLERANCE TEST HEMOGLOBIN A, GLYCOSYLATED AGED INSULIN BLOOD GLUCOSE SPECTROPHOTOMETRY, ATOMIC ABSORPTION