| Author/Editor | Macedoni-Lukšič, M | |
| Title | Amfetaminski model psihoze pri podganah: modulacija dopaminskega sistema s holinergičnimi | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1993 | |
| Volume | str. 58 | |
| Language | slo | |
| Abstract | Treatment with amphetamine, an indirectly acting dopamine (DA) agonist, is a well known experimental animal model for schizophrenia. In rats, typical stereotyped behavior is induced by this drug. In the present study, the influence of either intermittent (one injection per day) or continuous (by osmotic minipumps - OMP) chronic administration of d-amphetamine on rat behavior were compared. In further experiments muscarinic antagonist scopolamine was given in addition to the chronic d-amphetamine regimen. Changes at the DA receptor levels produced by amphetamine treatment were indirectly analyzed a) by application of DA agonist apomorphine and scoring the stereotyped behavior and locomotor activity, b) by studying catalepsy induced by injection of D2-receptor antagonist haloperidol. After intermittent d-amphetamine administration, behavioral sensitization was observed with an increased degree of stereotypy beginning from the 3rd day till the end of one week treatment. Continuous d-amphetamine administration produced even higher degree of stereotypy on the 2nd day of treatment. However, behavioral tolerance on d-amphetamine administration developed gradually during the five consecutive days. Continuous scopolamine administration did not influence the rate of stereotypy in rats simultaneously treated with intermittent doses of d-amphetamine. However, behavioral tolerance to d-amphetamine after continuous d-amphetamine administration was significantly decreased by scopolamine. After intermittent d-amphetamine treatment, rats reacted to apomorphine with significantly higher stereotypy than those in the control group. After continuous d-amphetamine treatment, on the other hand, rats displayed nonsignificantly lower stereotypy in comparison to controls.(trunc.) | |
| Descriptors | PSYCHOSES, SUBSTANCE-INDUCED AMPHETAMINE SCOPOLAMINE APOMORPHINE HALOPERIDOL ANIMALS, LABORATORY RATS BEHAVIOR, ANIMAL LOCOMOTION CATALEPSY |