| Author/Editor | Strnad, Matej; Grmec, Štefek | |
| Title | Eritropoetin - nov terapevtski pristop pri oživljanju? | |
| Translated title | Erythropoietin - a new therapeutic approach to cardiopulmonary resuscitation? | |
| Type | članek | |
| Source | In: Grmec Š, Kupnik D, editors. Akutna stanja. Maribor: Zdravstveni dom dr. Adolfa Drolca, Center za nujno medicinsko pomoč in reševalne prevoza, | |
| Publication year | 2007 | |
| Volume | str. 243-51 | |
| Language | slo | |
| Abstract | In spite of effective prehospital and hospital medical treatment of patients in cardiac arrest and the increasing percentage of successfully resuscitated patients, in recent years an unsatisfactory poor neurological functional outcome is observed in these patients. Therefore it is important to give even more attention to better or more efficient intensive care of these patients after resuscitation. Led by the desire to preserve as much neurological functions as possible in the case of ischemic brain injury, several animal studies were conducted, which show that erythropoietin has potential to preserve and ecen improve neurological functions in hypoxic-ischemic brain injury. Application of exogenous recombinant erythropoietin at the site of the tissue can protect cells from apoptosis inside the penumbra and thus reduce the level of tissue injury by blocking programmed cell death. | |
| Summary | Predbolnišnična nujna medicinska pomoč pri svojem delu relativno pogosto obravnava bolnike v srčnem zastoju. V zadnjih letih smo kljub učinkoviti predbolnišnični in bolnišnični oskrbi bolnikov v srčnem zastoju in zviševanju odstotka uspešno oživljanih priča nezadovoljivemu nevrološkemu funkcionalnemu izhodu pri teh bolnikih. Zato je pomembno, da se še večja pozornost nameni kakovostnejši oziroma učinkovitejši poreanimacijski oskrbi teh bolnikov. V želji po čim boljši ohranitvi nevroloških funkcij v primeru možganske ishemije, je bilo do sedaj narejenih precej živalskih študij, ki so v primeru eritropoetina pokazale, da ima ta pomembno vlogo pri ohranitvi in celo izboljšanju nevroloških funkcij v primeru hipoksično-ishemičnih okvar možganovine. Aplikacija eksogenega eritropoetina na mesto tkivne poškodbe lahko zaščiti celice v penumbri pred apoptozo in tako zmanjša stopnjo tkivne poškodbe oz. izgube tkiva z zaustavitvijo apoptotskega programa. | |
| Descriptors | HEART ARREST APOPTOSIS NEUROLOGIC MANIFESTATIONS ERYTHROPOIETIN |