Author/Editor		Zorc-Pleskovič, R; Vraspir-Porenta, O; Zorc, M; Milutinovič, A; Petrovič, D
Title		Inflammatory changes in small blood vessels in the endomyocardium of cardiac syndrome X in female patients with increased C-reactive protein
Type		članek
Source		Folia biol Praha
Vol. and No.		Letnik 54
Publication year		2008
Volume		str. 30-2
Language		eng
Abstract		The pathogenesis and pathohistological changes of CSX, a syndrome characterized by anginal chest pain and normal coronary arteries on coronary angiography, is poorly understood. The purpose of this study was to analyse morphological changes in small blood vessels of the CSX patients with increased CRP levels (above 5 mg/l). EMB was performed for diagnosfic purposes in 3l female patients with CSX, and EMB specimens were histologically and immunohistochemically analysed. Increased CRPwas found in 18 (58.1%) femalepatients with CSX. Signs of inflammation in the walls of small blood vessels were demonstrated in 13 (76%) and TUNEL-positive endothelial cells in 3 (17%) women with increased CRP. Morphological analysis of small blood vessels in EMB in CSX female patients with increased CRP levels revealed signs of inflammation and apoptosis of endothelial cells, indicating the role of inflammation in the pathogenesis of CSX.
Descriptors		SYNDROME X ENDOCARDIUM C-REACTIVE PROTEIN HEART CATHETERIZATION CORONARY VESSELS BIOPSY IMMUNOHISTOCHEMISTRY ANTIGENS, CD45