Author/Editor     Gubenšek, J; Buturović-Ponikvar, J; Ponikvar, R
Title     Regional citrate anticoagulation for single-needle hemodialysis: a prospective clinical study
Type     članek
Source     Blood Purif
Vol. and No.     Letnik 25, št. 5-6
Publication year     2007
Volume     str. 454-6
ISSN     0253-5068
Language     eng
Abstract     Aim: Regional citrate anticoagulation protocol for single-needle hemodialysis was tested prospectively for safety and efficacy. Methods: 15 chronic dialysis patients at risk of bleeding were included. 4 % trisodium citrate (200 ml/h), calcium-free dialysate and 1 mol/l calcium chloride (7 ml/h) were used. After dialysis the antithrombotic effect in the circuit was assessed visually (grade 5, no clotting, to 1, total occlusion) and serum citrate was measured. Results: Of 32 dialyses performed, 94% were uneventful and in 2 cases (6%) there was severe (ionized calcium </=0.8 mmol/l) but asymptomatic hypocalcemia. Mean anticoagulation score after dialysis was 4.8 +/- 0.7 for the arterial bubble trap, 4.6 +/- 0.8 for the dialyzer and 4.8 +/- 0.7 for the venous bubble trap. Serum citrate after dialysis was 158 +/- 60 mumol/l. Conclusion: Regional citrate anticoagulation in single-needle dialysis is safe and efficient. Copyright (c) 2007 S. Karger AG, Basel.
Descriptors     KIDNEY FAILURE, CHRONIC
HEMODIALYSIS
HEMODIALYSIS SOLUTIONS
CITRATES
ANTICOAGULANTS
CALCIUM
SODIUM
BICARBONATES
HYDROGEN-ION CONCENTRATION