Author/Editor		Bilban, M
Title		Influence of the work environment in a Pb-Zn mine on the incidence of cytogenetic damage in miners
Type		članek
Source		Am J Ind Med
Vol. and No.		Letnik 34, št. 5
Publication year		1998
Volume		str. 455-63
Language		eng
Abstract		Background: Occupational, environmental, or experimental exposure of people, animals, and cell cultures to radon has been the subject of numerous studies. The present study comprised 120 miners, occupationally exposed to radon and heavy metals in a Pb-Zn mine; 57 female subjects environmentally exposed (control group 1); and 100 subjects from the urban population (control group 2). Methods: Radon measurements were performed, and the effective equivalent radiation doses over a 2-year period were calculated. The following end points were studied: conventional analysis of structural chromosomal aberrations, micronuclei, and sister chromatid exchanges (SCE). Results: The mean values of the percentage of structural chromosomal aberration frequency were 4.09% in miners, 1.43% in control group 1, and 1.88% in control group 2. The difference in frequencies was statistically significant (AV/FP 0.000). The frequency of micronuclei was 13.00 +/- 3.54 per 500 CB cell in miners and 6.4 +/- 2.11 per 500 CB cells in control subjects (AV/FP 0.000). The frequency of SCE was 7.97 per cell in miners (range 6.2-13.1) and 6.17 and 6.63 for the two control groups, respectively (AV/FP 0.000). Conclusions: Comparative analysis of the cytogenetic results for all three groups showed significant differences between the miners and the two control groups. The findings of this study need to be interpreted with regard to simultaneous exposure to radon and metals, i.e., lead, cadmium, and zinc.
Descriptors		CHROMOSOME ABERRATIONS METALS, HEAVY MINING OCCUPATIONAL EXPOSURE OCCUPATIONAL HEALTH RADON ADULT LEAD SISTER CHROMATID EXCHANGE ZINC