| Author/Editor | Franko, A; Dolžan, V; Arnerić, N; Dodič-Fikfak, M | |
| Title | The influence of genetic polymorphisms of GSTP1 on the development of asbestosis | |
| Type | članek | |
| Source | J Occup Environ Med | |
| Vol. and No. | Letnik 50, št. 1 | |
| Publication year | 2008 | |
| Volume | str. 7-12 | |
| Language | eng | |
| Abstract | Objective: Genetic factors play an important role in the development of asbestosis. The aim of this study was to investigate whether genetic polymorphisms of glutathione S-transferase (GST) P1 represent a risk factor for this disease. Methods: The study population included 262 workers with asbestosis and 265 matched controls. Information on cumulative asbestos exposure was available. A real-time PCR based on the 5' nuclease assay was designed for the analysis of GSTP1 Ile105Val and Ala114Val polymorphisms. Results: Asbestosis was associated with GSTP1 genotype coding for an enzyme with high conjugation capacity versus genotypes resulting in intermediate and low enzyme activity (odds ratio = 1.49, confidence interval = 1.06-2.10). Conclusion: The key finding of the study was that GSTP1 genotype coding for an enzyme with high conjugation capacity significantly increases the risk of developing asbestosis. | |
| Descriptors | ASBESTOS ASBESTOSIS OCCUPATIONAL EXPOSURE GLUTATHIONE TRANSFERASES POLYMORPHISM (GENETICS) GENOTYPE POLYMERASE CHAIN REACTION |