Author/Editor		Mijušković, ZP; Zečević, RD; Pavlović, MD
Title		Pyoderma gangrenosum with spleen involvement and monoclonal IgA gammopathy
Type		članek
Source		J Eur Acad Dermatol Venereol
Vol. and No.		Letnik 18, št. 6
Publication year		2004
Volume		str. 697-9
Language		eng
Abstract		A 46-year-old man with a 3-year history of pyoderma gangrenosum was admitted with ulceration (6 x 5 cm), on the right leg. Previously he had been treated with tapering doses of prednisone (maximum dose 1 mg/kg per day); however, he had had a few exacerbations following each taper of prednisone dose. Immunoelectrophoresis demonstrated monoclonal IgA gammopathy of lambda light chains. Abdominal echography and abdominal computed tomographic scan revealed multiple splenic abscesses. Treatment was started with oral prednisone (1 mg/kg per day) and cyclosporin (5 mg/kg per day) and 6 weeks later complete remission was achieved. Systemic involvement in pyoderma gangrenosum is very rare, and according to our knowledge there are only a few cases with spleen involvement.
Descriptors		CYCLOSPORINE HYPERGAMMAGLOBULINEMIA IMMUNOSUPPRESSIVE AGENTS PREDNISONE PYODERMA GANGRENOSUM SPLENIC DISEASES