Author/Editor		Ekart, Robert; Hojs, Radovan; Bevc, Sebastjan; Pečovnik-Balon, Breda
Title		Asymptomatic atherosclerosis and hypertension in nondiabetic patients with chronic kidney disease
Type		članek
Source		Artif Organs
Vol. and No.		Letnik 32, št. 3
Publication year		2008
Volume		str. 220-5
Language		eng
Abstract		Atherosclerosis is accelerated in dialysis patients, but less is known about asymptomatic atherosclerosis and major risk factors in patients with different stages of chronic kidney disease (CKD). We compared intima media thickness (IMT) and plaque occurrence in the carotid arteries in 104 nondiabetic patients (stages 1-5 of CKD; mean age: 51.6 years) with those in 40 healthy control subjects. The IMT values (0.69 vs. 0.59 mm; P < 0.002) were higher in patients. More patients had plaques (46.2 vs. 17.5%; P < 0.002), and number of plaques was higher (P < 0.003). Negative correlation between IMT (P < 0.0001), presence of plaques (P < 0.0001), their number (P < 0.040), and chromium 51-labeled ethylenediaminetetraacetate ((51)Cr-EDTA) clearance were found in patients. With multiple regression analysis, relationship between IMT and (51)Cr-EDTA clearance (P < 0.001) and presence of hypertension (P < 0.001) was found. Nondiabetic patients with CKD showed advanced atherosclerosis and IMT, plaque occurrence, and number increased directly with the level of renal dysfunction. Another important risk factor was hypertension.
Descriptors		ATHEROSCLEROSIS KIDNEY DISEASES CHRONIC DISEASE CORONARY DISEASE HYPERTENSION CAROTID ARTERIES SMOKING CHOLESTEROL TRIGLYCERIDES LIPOPROTEINS TUNICA INTIMA