Author/Editor		Ravlić-Gulan, Jagoda; Vrbanić, Tea Schnurrer-Luke; Boschi, Vladimir; Vogrin, Matjaž
Title		Patogenetski mehanizam sindroma zakašnjele mišićne boli
Type		članek
Source		Medicina Rij
Vol. and No.		Letnik 43, št. 3
Publication year		2007
Volume		str. 179-87
Language		ser
Abstract		Delayed onset muscle soreness (DOMS) is the feeling of pain, tenderness, deep ache and stiffness that usually develops 24-48 hours after an unaccustomed or a high intensity exercise and subsides generally within 5 to 7 days. Despite numerous studies there is no general consensus on the underlying mechanisms of DOMS, treatment or prevention strategies. A major causative factor is eccentric muscle actions, i. e. active resistance to muscle lengthening. However, the cellular basis for this response remains unclear. Eccentric activities induce micro-injury of muscle cells resulting in myofibrillar disruption, prolonged loss of muscle strength, decrements in motor control, changes in energy substrate levels and presence of muscle proteins in the blood. Some recent research claims that DOMS is not caused by the pain from damaged muscle cells and secondary induced inflammatory processes, but from the reinforcement process. The biological response of muscle to eccentric contractions results in strengthening and protection from further injury. The muscle responds to training by reinforcing itself up to and above its previous strength by adding new sarcomeres, the segments in the muscle fibrils (sacromerogenesis). In this review, we summarize the muscle cell disturbances and adaptation processes known to be involved in pathogenetic mechanisms of DOMS which could be of clinical importance in sports medicine.
Descriptors		MUSCLE CONTRACTION MUSCLES EXERCISE PAIN CREATINE KINASE