Author/Editor		Andoljšek, Dušan; Pajič, Tadej
Title		Odziv na dezmopresin (DDAVP) pri von Willebrandovi bolezni: preoperativno preverjanje
Translated title		Response to desmopressin (DDAVP): preoperative testing
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 77, št. Suppl 1
Publication year		2008
Volume		str. I-121-4
Language		slo
Abstract		Background The principle of treatment or prevention of bleeding in von Willebrand disease (vWd) is correction of dual plasma deficiency of von Willebrand factor (vWF) and factor VIII (F VIII). This can be achieved by desmopressin (DDAVP) or plasma fractions. DDAVP effect was tested in von Willebrand patients before surgical procedure. Methods DDAVP test was done in 13 vWd patients (type 1) by slow infusion of DDAVP (0.3 ug/bw Minirin, Ferring) in 100 ml of saline. Before, after 1, 4 hours venous blood sample was taken for F VIII:C, vWF:Rco, vWF:CBA, vWF:Ag. Results After 1 hour, preinfusion levels comparison showed, F VIII:C, vWF:CBA, vWF:Ag were 2‐4 times higher, vWF:RCo 2‐3 times higher. 4 hours later all the levels were one third to one fourth lower but still high enough to prevent bleeding. Conclusions DDAVP raises vWF in vWd patients (except type 3) and has efficacious hemostatic response as it prevents or stop bleeding. Using DDAVP test, 2‐4 times higher levels of F VIII and vWF were noticed 1 hour after DDAVP infusion. The data can help us to decide the optimal treatment to prevent and stop bleeding in vWd patients.
Descriptors		VON WILLEBRAND'S DISEASE DESMOPRESSIN FACTOR VIII VON WILLEBRAND FACTOR PREOPERATIVE CARE