Author/Editor		Ristić, Smiljana; Lovrečić, Luca; Starčević-Čizmarević, Nada; Brajenović-Milić, Bojana; Šega-Jazbec, Saša; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut
Title		Tumor necrosis factor-alpha-308 gene polymorphism in Croatian and Slovenian multiple sclerosis patients
Type		članek
Source		Eur Neurol
Vol. and No.		Letnik 57, št. 4
Publication year		2007
Volume		str. 203-7
Language		eng
Abstract		Previous findings regarding the role of TNF-alpha-308 gene polymorphism in multiple sclerosis (MS) are contradictory. The aim of this study was to investigate the possible influence of TNF-alpha-308 polymorphism on MS susceptibility and the MS disease process in a Croatian and Slovenian population. Genotyping was performed in 338 patients and 460 healthy controls. The TNF2 allele was present in 123 (26.8%) healthy controls vs. 67 (19.9%) MS patients (p = 0.023, odds ratio = 0.68, 95% confidence interval = 0.48-0.95), suggesting that carriage of the TNF2 allele might decrease MS risk. The difference in TNF2 allele carrier frequency between patients and controls was identified in the relapsing-remitting MS group. There was no association between TNF2 allele carrier status and age at disease onset or disease progression. Our results suggest that, in the study populations, the TNF-alpha-308 polymorphism may play a role in MS susceptibility.
Descriptors		ADULT ALLELES CROATIA GENOTYPE HETEROZYGOTE MULTIPLE SCLEROSIS SLOVENIA