Author/Editor		Šoštarič, Maja; Geršak, Borut; Preložnik-Zupan, Irena
Title		Srčna operacija pri bolniku s heparinom povzročeno trombocitopenijo
Translated title		Heparin induced thrombocytopenia and cardiac surgery
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 77, št. 3
Publication year		2008
Volume		str. 247-53
Language		slo
Abstract		Background Heparin induced thrombocytopenia (HIT) is a serious complication related to the heparin treatment and might lead to the life-threatening consequences such as arterial and venous thrombosis. The patient with HIT scheduled for cardiac surgery represents serious problem because heparin, most common used anticoagulation drug during cardiac surgery, must be avoided. Conclusions From the results of the recent clinical studies it seems that direct thrombin inhibitors, especially bivalirudin represent an acceptable alternative to the heparin anticoagulation during the cardiac surgery.
Summary		Izhodišča S heparinom povzročena trombocitopenija (heparin induced thrombocytopenia ‐ HIT) je resen zaplet zdravljenja s heparinom, ki lahko vodi do arterijskih in venskih tromboz. Poseben problem so bolniki s HIT, ki potrebujejo operacijo na srcu. Pri omenjenih bolnikih ne smemo uporabiti heparina kot antikoagulantno sredstvo med operacijo, ampak moramo izbrati drugo neheparinsko antikoagulantno zdravilo. Zaključki Ugotovitve kliničnih študij iz zadnjih let kažejo na to, da so zdravila iz skupine direktnih inhibitorjev trombina, še posebno bivalirudin, primerna kot antikoagulantno zdravilo med srčno operacijo.
Descriptors		THROMBOCYTOPENIA HEPARIN HEART DISEASES THROMBIN