Author/Editor		Nenadić, Dane B; Pavlović, Miloš D
Title		Cervical fluid cytokines in pregnant women: relation to vaginal wet mount findings and polymorphonuclear leukocyte counts
Type		članek
Source		Eur J Obstet, Gynecol, Reprod Biol
Vol. and No.		Letnik 140, št. 2
Publication year		2008
Volume		str. 165-70
Language		eng
Abstract		Objective: The purpose of the study was to measure and compare concentrations of IFN-gamma, IL-8, IL-10 and IL-12 in cervical fluids of pregnant women with normal and pathologic microscopic findings of vaginal wet mount. Study design: Vaginal samples were obtained from 100 pregnant women (22-32 weeks of gestation) without signs and symptoms of preterm labour (PTL), selected on the basis of the microscopic examination of vaginal wet mounts. Cytokine (IFN-gamma, IL-8, IL-10 and IL-12) concentrations were measured in cervical fluids by an enzyme-linked immunosorbent assay. Results: The cytokines were found in cervical fluids of the majority of pregnant women, with IFN-gamma and IL-8 detected in all samples. Concentrations of IL-8 were significantly higher in pregnant women with pathologic findings on vaginal wet mount, including elevated polymorphonuclear (PMN) cell counts. Conclusion: A significant correlation between microscopic findings and cervical fluid IL-8 concentrations may make vaginal wet mount microscopy a useful tool for identification of patients with cervicovaginal inflammation, which is considered a risk factor for spontaneous preterm delivery.
Descriptors		VAGINAL SMEARS INTERFERON TYPE II INTERLEUKIN-8 INTERLEUKIN-10 INTERLEUKIN-12 PREGNANCY LABOR, PREMATURE NEUTROPHILS LEUKOCYTE COUNT CERVICITIS VAGINITIS