Author/Editor		Markež, Jernej; Mulej, Marija; Resman, Janez; Arnež, Teja; Avberšek-Lužnik, Ivica
Title		N-končni natriuretični propeptid tipa B (NT-proBNP) in iztisni delež levega prekata v akutnem obdobju miokardnega infarkta z dvigom ST-spojnic in eno leto kasneje
Translated title		N-terminal natriuretic propeptide type-B (NT-proBNP) and left ventrocular ejection fraction in acute phase of ST-segment elevation myocardial infarction and 1-year later
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 76, št. 11
Publication year		2007
Volume		str. 663-8
Language		slo
Abstract		Background N-terminal natriuretic propeptide type-B (NT-proBNP) is a newer biochemical marker inacute coronary syndrome. NT-proBNP concentration of acute and chronic phase of STsegmentelevation myocardial infarction is a predictor of ventricular function and prognosis. Methods In a sequence of 35 patients (22 men, 13 women, mean age 66.4 ± 9.6 years) with first STEMI an NT-proBNP plasma concentration and echocardiography was performed in acute phase and one year later. A comparison of NT-proBNP values of both phases was done. In addition, a correlation among NT-proBNP, ejection fraction (EF) and E/Em ratio was analysed. Results NT-proBNP concentration measured in STEMI acute phase was significantly higher in comparison with the value measured one year later (1833 pg/ml:419 pg/ml, p < 0.001). NT-proBNP was significantly higher in patients with anterior STEMI (n = 15) compared with the patients with inferior STEMI (n = 20) in acute phase and one year later. In patients with inferior STEMI a mean NT-proBNP value one year after infarction was below the limit values of 300 pg/ml (236 pg/ml). Between EF values in acute phase and one year later there was no significant difference (p = 0.667). 9 patients (26%) had EF lower than 50%. EF was significantly lower with anterior STEMI than with inferior one (p < 0.001). E/Em ratio betwen 2 groups showed no significant difference. A correlation between whole group NT-proBNP and ET was statistically insignificant and negative in STEMI acute phase (r = ‐0.526, p < 0.001) and one year later (r = ‐0.495, p < 0.003). Between NTproBNP and E/Em ratios no statistically significant difference was found. (Abstract truncated at 2000 characters)
Summary		Izhodišča N-končni natriuretični propeptid tipa B (NT-proBNP) je novejši biokemični označevalec pri akutnem koronarnem sindromu. Koncentracija NT-proBNP v akutnem in kroničnem obdobju miokardnega infarkta z dvigom ST-spojnic (STEMI) je kazalec prekatne funkcije in napovedi izida. Metode Pri 35 zaporednih bolnikih (22 moških,13 žensk; starost 66,4 ± 9,6 leta) s prvim STEMI smo izmerili plazemske koncentracije NT-proBNP in opravili ehokardiografijo v akutnem obdobju STEMI in leto dni kasneje. Primerjali smo koncentracije NT-proBNP v obeh obdobjih in analizirali povezave NT-proBNP z iztisnim deležem (EF) ter doplerskim kazalcem polnilnega tlaka levega prekata ‐ razmerjem E/Em. Rezultati Koncentracija NT-proBNP, merjena v akutnem obdobju STEMI, je bila značilno višja v primerjavi z letom dni kasneje (1833 pg/ml: 419 pg/ml, p < 0,001). Vrednost NT-proBNP je bila pomembno višja pri bolnikih s STEMI sprednje stene (n = 15) v primerjavi s STEMI spodnje stene (n = 20) v akutnem obdobju in ob letnem pregledu. Pri bolnikih s STEMI spodnje stene je bila srednja vrednost NT-proBNP eno leto po infarktu pod mejno koncentracijo 300 pg/ml (236 pg/ml). Med EF v akutnem obdobju in po enem letu ni bilo značilne razlike (p = 0,667). Devet bolnikov (26%) je imelo EF nižji od 50%. EF je bil pomembno nižji pri STEMI sprednje stene v primerjavi s STEMI spodnje stene (p < 0,001). Pri doplerskem razmerju E/Em med skupinama nismo ugotovili značilne razlike. V celotni skupini je bila povezava med NT-proBNP in EF statistično značilna in negativna v akutnem obdobju STEMI (r = ‐0,526, p < 0,001) in leto dni kasneje (r = ‐0,495, p < 0,003). Med NT-proBNP in razmerjem E/Em nismo odkrili statistično značilne povezave. (Izvleček prekinjen pri 2000 znakih)
Descriptors		MYOCARDIAL INFARCTION ECHOCARDIOGRAPHY STROKE VOLUME NATRIURETIC HORMONE CORONARY DISEASE