Author/Editor		Pal, Marjetka; Krajnc, Ivan; Potočnik, Uroš
Title		Osteoartritis: patogeneza in farmakološko zdravljenje
Type		članek
Source		Med Mes
Vol. and No.		Letnik 4, št. 3/4
Publication year		2008
Volume		str. 88-93
Language		slo
Abstract		Osteoarthritis is a progressive disorder characterized by destruction of articular cartilage and subchondral bone and by synovial changes. Alleviation of pain and inhibition of inflammation are the primary goals of pharmacotherapy of osteoarthritis (OA). Disease modifying therapy is under development. Current knowledge about pathogenesis of OA reveals new pharmacological targets.
Summary		Osteoartritis (OA) je progresivna bolezen, za katero je značilna razgradnja sklepnega hrustanca in subhondralne kosti ter sinovialne spremembe. Zmanjšanje bolečine in zaviranje vnetja sta trenutna primarna cilja farmakoterapije osteoartritisa (OA). Terapija, ki bo vplivala na sam potek bolezni, je komaj v razvoju. Z znanjem o patogenezi OA se odkrivajo tudi nove farmakološke tarče.
Descriptors		CARTILAGE, ARTICULAR BONE AND BONES OSTEOARTHRITIS