Author/Editor		Pal, Marjetka; Krajnc, Ivan
Title		Osteoimunologija: RANKL/RANK/OPG citokinski sistem
Type		članek
Source		Med Mes
Vol. and No.		Letnik 4, št. 3/4
Publication year		2008
Volume		str. 94-7
Language		slo
Abstract		The concept of osteoimmunology is that certain molecules link the skeletal and immune system. The receptor activator of nuclear factor-kappaB ligand (RANKL), its receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. A critical element in osteoimmunology is the inducible transcription factor nuclear factor-kappaB (NF-kB), which regulates gene expression during inflammatory, immune responses and osteoclast differentiation.
Summary		Koncept osteoimunologije je, da obstajajo povezovalne molekule med skeletnim in imunskim sistemom. Ligand receptorja za aktivator jedrnega dejavnika kB (RANKL), njegov receptor RANK in naravni vabni receptor osteoprotegerin so ključne molekule osteoklastne kostne resorpcije. Pomemben element v osteoimunologiji je inducibilni transkripcijski jedrni dejavnik kB (NF-kB), ki regulira gensko ekspresijo med vnetnimi, imunskimi odgovori ter med osteoklastno diferenciacijo.
Descriptors		BONE AND BONES BONE REMODELING