Author/Editor		Felfernig, M; Salat, A; Kimberger, O; Gradišek, P; Muller, MR; Felfernig, D
Title		Preemptive analgesia by lornoxicam - an NSAID - significantly inhibits perioperative platelet aggregation
Type		članek
Source		Eur J Anaesthesiol
Vol. and No.		Letnik 25, št. 9
Publication year		2008
Volume		str. 726-31
Language		eng
Abstract		Background and objectiveTo investigate whether preemptive administered lornoxicam changes perioperative platelet function during thoracic surgery. Methods: A total of 20 patients scheduled for elective thoracic surgery were randomly assigned to receive either lornoxicam (16 mg, i.v.; n = 10) or placebo (n = 10) preoperatively. All patients underwent treatment of solitary lung metastasis and denied any antiplatelet medication within the past 2 weeks. Blood samples were drawn via an arterial catheter directly into silicone-coated Vacutainer tubes containing 0.5 mL of 0.129 M buffered sodium citrate 3.8% before, 15 min, 4 h and 8 h after the study medication was administered. Platelet aggregation curves were obtained by whole blood electrical impedance aggregometry (Chrono Log(R)). Results: Platelet aggregation was significantly reduced 15 min, 4 h and 8 h after lornoxicam administration compared to placebo (P < 0.05) for collagen, adenosine diphosphate and arachidonic acid as trigger substances. Adenosine diphosphate-induced platelet aggregation decreased by 85% 15 min after lornoxicam administration, and remained impaired for 8 h.ConclusionPlatelet aggregation assays are impaired for at least 8 h after lornoxicam application. Therefore perioperative analgesia by use of lornoxicam should be carefully administered under consideration of subsequent platelet dysfunction.
Descriptors		THORACIC SURGERY PAIN, POSTOPERATIVE ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL PLATELET AGGREGATION INHIBITORS COLLAGEN ARACHIDONIC ACID PLATELET AGGREGATION