Author/Editor		Toplak, N
Title		Recurrent fever in children as a diferential diagnostic challenge
Translated title		Diagnostični pristop k otrkou s ponavljajočimi vročinskimi stanji
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 15, št. 1
Publication year		2008
Volume		str. 24-9
Language		eng
Abstract		The approach to a child with a prolonged, recurrent or periodic fever presents a diagnostic challenge. A careful history, physical examination, laboratory testing and imaging studies are needed in order to exclude acute or chronic infection, anatomical defects, immunodeficiency, and autoimmune and malignant diseases. Periodic fever syndromes are defined as three or more episodes of unexplained fever in a 6-month period, occurring at least 7 days apart. Specific genetic mutations have been discovered for these syndromes. Sporadic conditions, such as Periodic fever syndrome with aphthous stomatitis, pharyngitis and cervical adenopathy have also been recognized. Periodic fever syndromes belong to a group of autoinflammatory disorders in which no pathogen, autoantibodies or antigen specific T cells can be found. They are caused by mutations in proteins that modulate the activity of the inflammasome. Because of the defective innate immune response these diseases are listed among the primary immunodeficiencies.
Descriptors		FEVER OF UNKNOWN ORIGIN RECURRENCE HYPERGAMMAGLOBULINEMIA RECEPTORS, TUMOR NECROSIS FACTOR PERIODIC DISEASE DIAGNOSIS, DIFFERENTIAL CHILD