Author/Editor | Dastychova, E; Nečas, M; Vašku, V | |
Title | Contact hypersensitivity to selected excipients of dermatological topical preparations anf cosmetics in patients with chronic eczema | |
Type | članek | |
Source | Acta Dermatovenerol Alp Pannon Adriat | |
Vol. and No. | Letnik 17, št. 2 | |
Publication year | 2008 | |
Volume | str. 61-8 | |
Language | eng | |
Abstract | Objective: 1) Assessment of the frequency of contact sensitization to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. 2) Detection of the sources of sensitization. Methods: 1,927 patients with chronic eczema (mean age 44.3 years, 601 males, 1,326 females) were patch tested with selected excipients. Results: The main rates of sensitization observed were: thiomersal 11.3%, wool alcohols 4.0%, phenylmercuric acetate 3.1%, formaldehyde 2.5%, dodecyl gallate 2.0%, Bronopol 1.9%, dibromodicyanobutane/phenoxyethanol (1:4) 1.7%, chloracetamide 1.6%, chlorhexidine digluconate 1.5%, Kathon CG 1.4%, parabens 1.1%, diazolidinyl urea 0.9%, imidazolidinyl urea 0.7%, benzalkonium chloride 0.7%, and Quaternium-15 (quaternary ammonium salt) 0.7%. Conclusion: The rate of sensitization to the excipients included in dermatological topical preparations and cosmetics in patients with chronic eczema is significant. Complete information on all the ingredients is necessary. | |
Descriptors | ECZEMA DERMATITIS, CONTACT EXCIPIENTS ANTIOXIDANTS |