Author/Editor		Thangarajh, Mathula; Masterman, Thomas; Rot, Uroš; Duvefelt, Kristina; Brynedal, Boel; Karrenbauer, Virginija Danylaite; Hillert, Jan
Title		Increased levels of APRIL (a proliferation-inducing ligand) mRNA in multiple sclerosis
Type		članek
Source		J Neuroimmunol
Vol. and No.		Letnik 167, št. 1-2
Publication year		2005
Volume		str. 210-4
Language		eng
Abstract		B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL-a promotor of B-cell survival-in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls. APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing-remitting MS, albeit not significantly. MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL.
Descriptors		ADULT AGED B-LYMPHOCYTES BLOTTING, WESTERN CELL COUNT CHILD CHILD, PRESCHOOL GENE EXPRESSION REGULATION INFANT INFANT, NEWBORN LEUKOCYTES MEMBRANE PROTEINS MULTIPLE SCLEROSIS RNA, MESSENGER