Author/Editor | Thangarajh, Mathula; Masterman, Thomas; Helgeland, Lars; Rot, Uroš; Jonsson, Malin V; Egil-Eide, Geir; Pirskanen, Ritva; Hillert, Jan; Jonsson, Roland | |
Title | The thymus is a source of B-cell-survival factors-APRIL and BAFF-in myasthenia gravis | |
Type | članek | |
Source | J Neuroimmunol Suppl | |
Vol. and No. | Letnik 178, št. 1-2 | |
Publication year | 2006 | |
Volume | str. 161-6 | |
Language | eng | |
Abstract | The accumulation of B cells in the thymus is a common feature of myasthenia gravis (MG). To understand whether factors enhancing B-cell survival are increased in MG, we studied the expression of APRIL, BAFF and three of their receptors in the thymus. In hyperplastic thymi, macrophages expressed APRIL and BAFF, and germinal-center B cells, BAFF-R. CD138-positive plasma cells were abundant in MG thymi. By contrast, BCMA-positive plasma cells were scarce. The expression of APRIL and BAFF in MG thymi may reflect the establishment of an environment favorable to B-cell survival. | |
Descriptors | ADULT AGED AGED, 80 AND OVER B-LYMPHOCYTES ENZYME-LINKED IMMUNOSORBENT ASSAY IMMUNOHISTOCHEMISTRY MEMBRANE GLYCOPROTEINS MEMBRANE PROTEINS MYASTHENIA GRAVIS PROTEOGLYCANS RECEPTORS, TUMOR NECROSIS FACTOR THYMUS GLAND |