Author/Editor		Eberl-Gregorič, E
Title		Vpliv humanih in humanim podobnih interferonov na bakterijo Legionella pneumophila
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1993
Volume		str. 50
Language		slo
Abstract		The influence of human and human-like interferons (IFN) on cells, infected with bacteria Legionella pneumophila was studied. At first, bacteria Legionella pneumophila was cultivated on WiREF cells and infective dose of bacteria, able to cause plaques, was estimated. Next, the effect of interferons on legionella infected WiREF cells was tested. It was found that cells pretreated with interferon a developed the "antibacterial state", analogous to antiviral state and were more resistent to following infection with bacteria Legionella pneumophila. Farther experiments were performed to find poible enhancement of antibacterial protection if combinations of interferons (alpha and gamma) with antibiotics (Erythromycin, Rifamycin and Midecamycin acetat) were used. It was found that combination of Hu IFN a and antibiotics slightly enhanced the antibacterial state. In case of Hu IFN gamma this effect was seen only in combination with Midecamycin acetat.
Descriptors		LEGIONELLA PNEUMOPHILA INTERFERONS CELLS, CULTURED ANTIBIOTICS, MACROLIDE INTERFERON-ALPHA INTERFERON TYPE II ERYTHROMYCIN RIFAMYCINS INTERFERON ALFA, RECOMBINANT