Author/Editor		Šmuc, Tina; Hevir, Neli; Ribič-Pucelj, Martina; Husen, Bettina; Thole, Hubert; Lanišnik-Rižner, Tea
Title		Disturbed estrogen and progesterone action in ovarian endometriosis
Type		članek
Source		Mol Cell Endocrinol
Vol. and No.		Letnik 301
Publication year		2009
Volume		str. 59-64
Language		eng
Abstract		Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion. In the present study,we have examined the expression of 11 estrogen and progesterone metabolizing enzymes and their corresponding receptors in samples of ovarian endometriomas and control endometrium. Expression analysis revealed significant up-regulation of enzymes involved in estradiol formation (aromatase, sulfatase and all reductive 17alpha-hydroxysteroid dehydrogenases) and in progesterone inactivation (AKR1C1 and AKR1C3). Among the estrogen and progesterone receptors, ERalpha was down-regulated, ER was up-regulated, and there was no significant difference in expression of progesterone receptors A and B (PRAB). Our data indicate that several enzymes of estrogen and progesterone metabolism are aberrantly expressed in endometriosis, which can lead to increased local levels of mitogenic estradiol and decreased levels of protective progesterone. Changes in estrogen receptor expression suggest that estradiol may also act via non-estrogen receptor-mediated pathways, while expression of progesterone receptors still needs further investigation.
Descriptors		ENDOMETRIOSIS OVARIAN DISEASES 17-HYDROXYSTEROID DEHYDROGENASES RECEPTORS, ESTROGEN RECEPTORS, PROGESTERONE PROGESTERONE PROMOTER REGIONS (GENETICS) ALDEHYDE REDUCTASE IMMUNOHISTOCHEMISTRY ADULT