Author/Editor | Dungen, Hans-Dirk; Apostolović, Svetlana; Inkrot, Simone; Tahirović, Elvis; Krackhardt, Florian; Pavlović, Milan; Putniković, Biljana; Lainščak, Mitja; Gelbrich, Goetz; Edelmann, Frank | |
Title | Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial | |
Type | članek | |
Source | Clin Res Cardiol | |
Vol. and No. | Letnik 97, št. 9 | |
Publication year | 2008 | |
Volume | str. 578-86 | |
Language | eng | |
Abstract | Background: Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have further not been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data on the use of different beta-blockers in patients with CHF is scarce. AIM: To compare the tolerance of bisoprolol and carvedilol in elderly patients with CHF. Methods: CIBIS-ELD is an investigator-initiated, multi-centre, 1:1 randomised, double-blind, phase III trial comparing bisoprolol and carvedilol in patients >/=65 years with systolic or diastolic CHF. Recruitment started in April 2005 and is anticipated to be completed by April 2008 with at least 800 patients enrolled. Perspective: This is the first large scale head to head beta-blockers trial in an elderly population with CHF. Besides determining which of two standard beta-blockers is best tolerated in elderly patients with systolic or diastolic CHF, we expect to gain further insight into the treatment of the particular population of patients with diastolic CHF. | |
Descriptors | HEART FAILURE, CONGESTIVE ADRENERGIC BETA-ANTAGONISTS BISOPROLOL DOUBLE-BLIND METHOD RANDOMIZED CONTROLLED TRIALS MULTICENTER STUDIES |