Author/Editor		Pečovnik-Balon, B; Kolenc, M
Title		Vpliv kalcitriola na plazemske koncentracije kalcija, fosfata, alkalne fosfataze in parathormona pri bolnikih na hemodializi
Translated title		The effect of calcitriol on plasmic concentrations of calcium, phosphate, alcaline phosphatase and parathormone in patients on hemodialysis
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 62, št. 6
Publication year		1993
Volume		str. 245-8
Language		slo
Abstract		Background. When glomerular filtration (GF) drops to 25 percent of its normal value, the concentration of phosphate (P) in blood begins to rise. The retention of P lowers the concentration of ionozed calcium in blood, the consequence of which is an increase in the plasmic concentration of parathormone (PTH). A decreased plasmic concentration of 1.25 (OH)2D3 vitamin-calcitriol also has a great influence on secondary hyperpara-thyroidism. Methods. In 1991-1992, 51 patients were treated with hemodyalisis at Maribor Teaching Hospital. From among them 16 patients with a concentration of Ca in blood under 2.7 mmol/l, a concentration of P under 1.8 mmol/l and a concentration of PTHi over 65 og/ml were administred. All patients were put on a diet with low P as well as phosphate binders if it was necessary. The group of patients not receiving the calcitriol therapy was divided into two subgroups: one with normal and the other with abnormal plasmic concentrations of Ca and P. A comparison of the dynamic of awerage plasmic concentrations of P, Ca, AP, PTHi in these three groups was carried out. Results. In the group of patients treated with calcitriol, the awerage plasmic concentration of Ca increased from 2.09 +- 0.12 mmol/l to 2.5 +- 0.9 mmol/l - P < 0.001. The average plasmic concentration of AP dropped from 1.92 +- 1.77 micro kat/l to 0.91 +- 0.55 micro kat/l - P < 0.02. The awerage plasmic concentration of PTHi dropped from 192 +- 136 pg/ml to 92 +- 98 pg/ml - P < 0.025. The results were evaluated statistically by means of Student's t-test. Conclusions. Ou experience corresponds with that of American authors who report that peroral calcitriol in small doses is the "therapy of choice" in patients with low initial plasmic concentration of Ca and moderate plasmic concentration of PTHi. Otherwise "oral pulse calcitriol" or parenteral calcitriol in high doses is used.
Descriptors		HYPERPARATHYROIDISM, SECONDARY CALCITRIOL HEMODIALYSIS KIDNEY FAILURE RENAL OSTEODYSTROPHY CALCIUM PHOSPHATES ALKALINE PHOSPHATASE PARATHYROID HORMONES