Author/Editor		Vlaisavljević, Veljko; Reljič, Milan; Mlakar, Lea; Muršič, Jasna
Title		Izidi nosečnosti po oploditvi z biomedicinsko pomočjo v Mariboru
Translated title		Pregnancy outcomes after assisted reproduction techniques in Maribor
Type		članek
Source		In: Takač I, editor. 80 let hospitalne ginekologije in porodništva v Mariboru: mednarodni znanstveni simpozij, Univerzitetni klinični center Maribor, Maribor, 17. 10. 2008. Maribor: Univerzitetni klinični center,
Publication year		2008
Volume		str. 401-10
Language		slo
Abstract		Specific factors that influence the outcome of pregnancies conceived with assisted reproductive technologies (ART) are infertility per se, increased age of parents, increased multiple pregnancy rates, direct effect of fertility drugs, effect of culture media and conditions on early cell division and genetic influences. So it is very important to focus our attention on obstetric outcome of pregnancy after ART. This paper analyzes the outcome of clinical pregnancies achieved after various methods of ART at our center between the years 1995 and 2005. In this period the achieved clinical pregnancies after ART resulted in 1835 deliveries. 2432 children were born, 48 were stillborn and there were 30 cases of early neonatal death. The overall frequency of multiple pregnancies was 31.2 %, 29.8% twins and 1.4 % triplets. Premature delivery occured in 19.6 %. The frequency of ceasarean sections was 50.9 %. The congenital malformation rate was 2 %. Multiple pregnancies represent the main problem of ART. The quality of IVF programs should be measured by percent of singleton pregnancies.
Summary		Specifični dejavniki, ki lahko vplivajo na izid nosečnosti, spočete s postopki oploditve z biomedicinsko pomočjo (OBMP), so neplodnost, starost staršev, visok delež večplodnih nosečnosti, učinek zdravil, ki jih uporabljamo za zdravljenje neplodnosti, učinek gojišč in pogojev kultiviranja na zgodnjo delitev zarodkov ter genetski dejavniki. Zato je zelo pomembno usmeriti pozornost na izid nosečnosti po postopkih OBMP. V prispevku smo analizirali izid nosečnosti po spočetju s postopki OBMP v našem centru med leti 1995 in 2005. V tem obdobju je po postopkih OBMP zanosilo in rodilo 1.835 žensk. Rodilo se je 2.432 otrok, 48 je bilo mrtvorojenih, pri 30 je prišlo do zgodnje neonatalne smrti. Večplodnih nosečnosti je bilo 31,2 %, 29,8% dvojčkov in 1,4 % trojčkov. Do prezgodnjega poroda je prišlo v 19,6 %. Nosečnost se je končala s carskim rezom v 50,9 %. Pri otrocih smo ugotovili prirojene nepravilnosti v 2 %. Večplodne nosečnosti predstavljajo glavni problem postopkov OBMP, zato bi bilo potrebno delež enoplodne nosečnosti upoštevati kot najpomembnejše merilo kvalitete izvajanje ter postopkov.
Descriptors		PREGNANCY, MULTIPLE PREGNANCY OUTCOME