Author/Editor		Mayr-Kanhaeuser, S; Kranke, B; Aberer, W
Title		Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne
Type		članek
Source		Acta Dermatovenerol Alp Panonica Adriat
Vol. and No.		Letnik 17, št. 3
Publication year		2008
Volume		str. 139-43
Language		eng
Abstract		Background: With the increase in antibiotic-resistant strains of microorganisms in acne lesions, the search for alternative treatment methods has become important. We studied the efficacy of a combination of the antiseptic substances octenidine dihydrochloride and 2-phenoxyethanol (O/P) in mild to moderate inflammatory acne vulgaris. Methods: Thirty patients were instructed to apply O/P once or twice daily for a 6-week treatment period. Determination of efficacy included the numerical documentation of inflammatory and non-inflammatory lesions within defined regions of the face by the investigator, and photodocumentation of the clinical picture as well as the fluorescence pattern under Wood's light. Results: Twenty-four patients completed the study. The number of papules and pustules decreased more than 50% in seventeen and nineteen patients, respectively. Acne lesions worsened in only one patient. Mild adverse reactions (erythema, burning, and scaling) were seen in two patients. Therefore, O/P was highly effective in treating inflammatory lesions of facial acne, but there was no essential efficacy in the non-inflammatory primary acne lesions. Conclusion: Topical O/P is a good and cost-effective alternative in the treatment of mild to moderate inflammatory acne lesions and may allow reduced application of anti-acne antibiotics to prevent development of resistance.
Descriptors		ACNE VULGARIS ANTI-INFECTIVE AGENTS, LOCAL ADMINISTRATION, TOPICAL