Author/Editor		Skok, Pavel; Kupnik, Dejan; Vujnović, Grujica
Title		Mallory-Weissov sindrom: pregled trinajstletnega obdobja
Translated title		Mallory-Weiss syndrome: review of a thirteen-year period
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 77, št. 9
Publication year		2008
Volume		str. 579-83
Language		slo
Abstract		Background. Acute upper gastrointestinal hemorrhage is a frequent problem of emergency medicine. Mallory-Weiss syndrome, a laceration at the esophagogastric junction, is an uncommon source of acute upper gastrointestinal hemorrhage. The purpose of the study was to evaluate the incidence of Mallory-Weiss tear and to assess the efficiency of endoscopic and supportive treatment in a prospective, cohort study. Patients and methods. The study includes patients with emergency endoscopy due to acute upper gastrointestinal methods hemorrhage between January 1, 1994 and December 31, 2006. Results. 7921 patients were investigated: 3010 female (38 %) and 4911 male (62 %), their average age was 59.5 years, SD +/- 17.3, with a 1-106 year span. In 228 patients (2.9 %, 165 male, av. age 52 years, SD +/- 17.1, range 7-90 years and 63 female, av. age 58.8 years, SD +/- 19.2 years, range 20-94 years) a Mallory-Weiss tear was found. In 136 patients (59.5 %) emergency endoscopy revealed signs of acute or traces of previous hemorrhage. Different methods of endoscopic hemostasis were carried out in 105 cases (46 %), hemostasis was successful in 102 patients (97 %). The total mortality of our patients was 7.8 % (18/228 patients), the majority of them died due to concommitant diseases and complications during treatment. Conclusions. Urgent endoscopy with different hemostatic procedures and modern supportive treatment have significantly improved the outcome of patients with these source of upper gastrointestinal hemorrhage.
Summary		Izhodišča. Akutna krvavitev iz zgornje prebavne cevi je čest problem v nujni medicini. Raztrganina v predelu ezofagogastrične stičnice, sindrom Malloryu-Weiss, je redkejši vzrok akutne krvavitve iz zgornje prebavne cevi. Namen raziskave je ugotoviti pogostost tega vzroka krvavitve ter oceniti uspešnost endoskopskega in podpornega zdravljenja v prospektivni kohortni raziskavi. Bolniki in metode. Pri bolnikih, vključenih v raziskavo, smo v obdobju od 1. januarja 1994 do 31. decembra 2006 opravili nujno endoskopsko preiskavo zaradi akutne krvavitve iz prebavne cevi. Rezultati. Pregledali smo 7921 bolnikov, 3010 žensk (38 %) in 4911 moških (62 %), povprečne starosti 59,5 leta, SD +/- 17,3, v razponu od 1-106 let. Pri 228 bolnikih (2,9 %, 165 moških, povprečne starosti 52 let, SD +/- 17,1 leta in 63 žensk, povprečne starosti 58,8 leta, SD +/- 19,2 leta) smo ugotovili raztrganino sluznice Mallory-Weiss. Znake aktivne krvavitve ali sledove pretekle krvavitve smo pri nujni endoskopski preiskavi ugotovili pri 136 bolnikih (59,5 %, 136/228), hemostazo smo opravili pri 105 bolnikih (46 %), uspešna pa je bila pri 102 bolnikih (97 %). Umrljivost bolnikov s tem vzrokom krvavitve je bila 7,8 % (18/228 bolnikov), praviloma povezana s pridruženimi boleznimi. Zaključki. Izid endoskopskega ter podpornega zdravljenja bolnikov s tem vzrokom krvavitve je običajno ugoden, le pri manjšini lahko pridružene bolezni ali stanja vplivajo na neugoden potek in usodne zaplete.
Descriptors		MALLORY-WEISS SYNDROME GASTROINTESTINAL HEMORRHAGE ESOPHAGOGASTRIC JUNCTION HEMOSTASIS, ENDOSCOPIC MORTALITY