Author/Editor		Flisar, Dušan; Puklavec, Ludvik; Grmek, Marko; Trošt, Maja
Title		Slikanje SPECT dopaminskega prenašalca pri boleznih možganov
Translated title		SPECT imaging of dopamine transporter in brain disorders
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 77, št. 9
Publication year		2008
Volume		str. 635-40
Language		slo
Abstract		Background. Diagnosis of parkinsonism is based on medical history and clinical examination. When the signs of parkinsonism are obvious (tremor at rest, rigidity, bradykinesia), the diagnosis is relatively easy. However, problems appear when clinical signs are not typical or distinct enough for making the proper diagnosis. Dopamine transporter imaging with radioactive tracer 123I-Ioflupane (DAT-SPECT) enables a clear evaluation of nigrostriatal degeneration and helps a clinician to make a correct diagnosis. This article discusses the role and indications of DAT-SPECT imaging in patients with movement disorders and in patients with dementia. Conclusions. DAT-SPECT enables clear differentiation of degenerative parkinsonisms from parkinsonisms and non-parkinsonian tremors in which the nigrostriatal pathway remains intact. DAT-SPECT also differentiates dementia with Lewy bodies from Alzheimer's disease.
Summary		Izhodišča. Diagnozo parkinsonizma postavimo na osnovi anamneze in kliničnega pregleda. Kadar so znaki parkinsonizma jasno izraženi (tremor v mirovanju, rigor, bradikineza), je diagnoza enostavna. Težave se pojavijo, ko klinični znaki niso značilni ali dovolj izraziti. Slikanje SPECT dopaminskega prenašalca z radioaktivnim označevalcem 123I-Ioflupanom (DAT-SPECT) omogoča zanesljivo oceno degeneracije nigrostriatalne poti in pomaga kliniku k pravilni diagnozi. Članek obravnava vlogo in indikacije slikanja DAT-SPECT pri bolnikih z motnjami gibanja in pri bolnikih z demenco. Zaključki. Slikanje DAT-SPECT omogoča zanesljivo ločevanje degenerativnih parkinsonizmov od parkinsonizmov in neparkinsonskih tremorjev, pri katerih je nigrostriatalna pot ohranjena. DAT-SPECT loči tudi demenco z Lewyevimi telesci od Alzheimerjeve bolezni.
Descriptors		MOVEMENT DISORDERS PARKINSON DISEASE DEMENTIA TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON TREMOR