Author/Editor		Kamenšek, Urška; Serša, Gregor
Title		Targeted gene therapy in radiotherapy
Translated title		Ciljana genska terapija v radioterapiji
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 42, št. 3
Publication year		2008
Volume		str. 115-35
Language		eng
Abstract		The dramatic pace in development of gene therapy over the past decades has made it a realistic alternative for the treatment of cancer. Radiotherapy, on the other hand, is one of the most commonly used and well established cancer treatment modalities. The latest improvements in the physical targeting ability of radiotherapy and understanding of the molecular mechanism involved in the cellular response to ionizing radiation have presented an opportunity to combine radiotherapy with gene therapy. This review article will focus on gene therapy strategies that can be used to enhance the effectiveness of radiotherapy, with an emphasis on transcriptional targeting approaches.
Descriptors		GENE THERAPY TRANSCRIPTION, GENETIC PROMOTER REGIONS (GENETICS) IMMUNOTHERAPY NEOPLASMS